For the last few decades, the rate of infertility in the United States has increased. Infertility is defined as not being able to get pregnant (conceive) after one year of trying. It has been estimated that between 16 and 25% of all couples have serious difficulty getting pregnant. Approximately 7.4% of women and their husbands in the United States are infertile and that the number of infertile people in the world may be as high as 15%, particularly in industrialized nations like the United States.

The Men’s Side of the Equation

For men, what appears clear is that environmental factors are playing an extremely strong role in low sperm counts and poor swimmers. You can see this because the supplements that work for infertility are the same ones that are combating the chemical assaults on the body.

Male sperm counts are declining, and environmental factors, such as pesticides, exogenous estrogens, and heavy metals may be the cause. Several studies have been conducted in the Czech Republic regarding men living in two different locations, one more polluted than the other. Men who are exposed to higher levels of air pollution were more likely to experience abnormal sperm morphology, decreased motility, and an increased chance of DNA fragmentation.

For men, semen parameters begin a steady decline as early as age 35. After the age of 40, men can have significantly more DNA damage in their sperm, as well as a decline in both motility (40%) and viability (below 50%). Combine a later age with high DNA damage from chemical assaults, and your swimmers are not going to finish the race.

Exercise and Male Fertility

Physically active men who exercised at least three times a week for one hour typically scored higher in almost all sperm parameters in comparison to men who participated in more frequent and rigorous exercise. Moderately physically active men had significantly better sperm morphology. Due to the design of the bike seat and tight spandex, it shouldn’t come as a surpise that bicycling more than five hours per week has been demonstrated to have a negative correlation with both total motile sperm counts and sperm concentration.

Diet and exercise together in obese male rats has been shown to increase both sperm motility, sperm morphology, and to decrease both sperm DNA damage and reactive oxygen species.

Fat Loss and Antioxidants for Male Fertility

A study conducted in mice demonstrated that leptin was nearly five times higher in obese mice than lean mice and that the higher leptin levels corresponded to five times lower fertility in the obese mice. It was also noted that there was a down-regulation of the leptin receptors located on the testes, possibly indicating that leptin resistance could play a role in male infertility.

A recent 2016 study found supplements that have demonstrated positive effects on male fertility on small randomized controlled trial (RCT) include aescin, coenzyme Q10, glutathione, Korean red ginseng, L-carnitine, black cumin seed oil, omega-3, selenium, a combination of zinc and folate, and the Menevit antioxidant.

Studies have proven a number of nutritional therapies have been shown to improve sperm counts and sperm motility, including L-carnitine, L-arginine, zinc, selenium, and vitamin B-12. Numerous antioxidants have also proven beneficial in treating male infertility, such as vitamin C, vitamin E, glutathione, and coenzyme Q10.

One study found that an overabundance of ROS may compromise sperm function, including sperm motility, altering DNA and decreasing membrane integrity. A Cochrane review including 34 studies, determined that men who use oral antioxidants had a significant increase in live birth rate when compared to control. Antioxidants were also associated with a significant increase in pregnancy rate when compared to control. 

Studies go back and forth as to which antioxidants have successful outcomes, and this is most likely due to individual biochemistry. The Nutrition Genome Report is a great way for you to understand where the biggest sources of inflammation are coming from, and what particular antioxidants are needed in higher amounts for optimal protection.

Stress and Male Fertility

Males who experienced more than two stressful life events before undergoing infertility treatment were more likely to be classified below WHO standards for sperm concentration, motility, and morphology. In a study including 950 men conducted by stress such as a job, life events, and even social strain were seen to have a significant impact on sperm density, total sperm counts, forward motility, and morphology.

Semen parameters may potentially be linked to stress. Stress and depression are thought to reduce testosterone and luteinizing hormone (LH) pulsing, disrupt gonadal function, and ultimately reduce spermatogenesis and sperm parameters. Even just the perceived stress of providing a semen sample was reported to be negatively linked to overall semen quality with a 39% decrease in sperm concentration, 48% decrease in motility, and worse overall semen parameters on the day of oocyte retrieval.

Cell Phones

It is strange to me that this is considered somewhat controversial, but if you keep portable radiation in your pocket, it really isn’t controversial. Cell phone usage has been linked with decreases in progressive motility of sperm, decreases in sperm viability, increases in free radicals, increases in abnormal sperm morphology (shape), and decreases in sperm counts.

One study evaluating 52 men demonstrated that men who carried a cell phone around the belt line or hip region were more likely to have decreased sperm motility compared to men who carried their cell phones elsewhere or who did not carry one at all.

One gene being explored for electrical sensitivity is CACNA1C, a calcium voltage-gated channel which mediates calcium inside the cell. Too much calcium is excitatory and harmful, which is what happens with glutamate stays too high for too long.

The Women’s Side of the Equation

When under the age of 30, a woman’s chances of conceiving may be as high 71%; when over 36, it may only be 41%. The number of infants born begins to exponentially decrease after the age bracket of 35–39. For women, being underweight and having extremely low amounts of body fat are associated with ovarian dysfunction and infertility. Approximately 20.7% of infertile women seeking intrauterine insemination (IUI) had also been diagnosed with an eating disorder.

Studies have found that folate, vitamin B6, vitamin C, vitamin D, vitamin E, iodine, selenium, iron, and DHA might have a positive impact on infertility treatment on female fertility. Other research has found magnesium to be a very key player in female fertility.

Women who take multivitamins may be less likely to experience ovulatory infertility; women who take six or more tablets had the lowest relative risk for infertility. This shows you how important supplementation can be.

Vitamin C and Female Fertility

Results from a study showed that the group receiving vitamin C had an increase in progesterone levels. The rate of pregnancy was significantly higher in the vitamin C group: 25% within six months, while only 11% of the untreated women became pregnant in the same time period. Large quantities of ascorbic acid are utilized by the female during conception and are necessary to formation and integrity of the fetal membranes. Research suggests vitamin C supplementation may also help prevent birth defects.

Certain variants in COMT, NOS, SHBG and SOD can increase your need for vitamin C.

Folate and Female Fertility

For those of you familiar with MTHFR 677, you know how important methylfolate is for fertility. You also know why it is so important to avoid supplements and processed foods with folic acid. But why is folate so important for fertility? I will explore this more in depth with its own article.

Magnesium, Selenium and Female Fertility

One one study, six women with a history of unexplained infertility or early miscarriage and who had failed to normalize their red cell magnesium (RBC-Mg) levels after four months of oral magnesium supplementation (600 mg/day) were investigated for red cell glutathione peroxidase activity.

They were compared with six age-matched women with a history of unexplained infertility or miscarriage who did normalize their RBC-Mg levels on magnesium supplementation. The six non-normalizers had significantly lower glutathione levels than the six normalizers.

After a further two months of 200 micrograms daily oral selenium as selenomethionine and oral magnesium supplements, all six women normalized their magnesium and RBC-selenium levels. All 12 previously infertile women have produced normal healthy babies all conceiving within eight months of normalizing their RBC-Magnesium levels.

How Might You Be Deficient in Selenium?

Selenium ranges widely in our soil and one of the best sources is from the sea. Due to pollution, our seafood consumption has dropped dramatically. If you have certain gene variants in glutathione, you may have a higher need for selenium to neutralize chemical assaults.

How Might You Be Deficient in Magnesium?

One of the most important genes for magnesium is COMT, which requires magnesium and vitamin C to work optimally. Certain variants increase your need for magnesium to modulate dopamine, adrenaline and estrogen. The US government study often cited shows 68% of Americans are deficient in magnesium based on dietary intake (which is high to begin with) is incredibly inaccurate based on the percentage of those with the numerous habits that deplete magnesium. Read more about magnesium deficiency here. See the chart below.

Magnesium Deficiency Flow Chart 4

Exercise and Female Fertility

While exercise is beneficial for fertility, vigorous exercise for women at a normal weight may be preventing pregnancy. According to a study led by U.S. and Danish researchers, moderate physical activity was associated with a small increase in fertility rates amount all women, but higher levels of vigorous exercise were associated with lower fertility rates in normal-weight women, but not over-weight or obese women. Physical activity has been shown to confer a protective effect on fertility when coupled with weight loss in obese women. A study examining 2,232 women undergoing in vitro fertilization (IVF) found that women who engaged in cardiovascular exercise for 4 hours or more per week for as little as one year prior to the treatment had a 40% decrease in live birth rate. as well as higher risks of cycle cancellation and implantation failure.

Stress and Female Fertility

One study found that women who had a job and worked more than 32 hours a week experienced a longer time to conception compared to women who worked 16 to 32 hours a week.

Food Sensitivities, Alcohol and Coffee

The two most widely spread food intolerances are gluten and dairy. You don’t need to have celiac disease to be sensitive to gluten. The FUT2 gene can tell you if there is a sensitivity to gluten and if it needs to be reduced in your diet.There is a proven link between food intolerances and anti-sperm antibodies. Studies have found that women with multiple allergies and food intolerances were more likely to miscarry. An overactive immune system is more likely to attack its own body cells.

From an immunological point of view, an embryo and sperm cell are foreign bodies. Our immune systems, however, are programmed to distinguish between a foreign body and a sperm cell or embryo. A normal and healthy immune response to an embryo or sperm cell is orchestrated by Th2 cytokines. They suppress your killer cells (that’s what they are called) to leave the embryo unharmed. An abnormal immune response to the implantation of the fertilized egg is orchestrated by Th1 cytokines. Rather than suppressing your killer cells they stimulate their activity. This can lead to defects and the loss of the fetus.

Alcohol and Coffee

Alcohol depletes B1, folate, vitamin C, zinc and disrupts intestinal bacteria. At a higher alcohol intake, infertility levels go up. If you are more prone to low levels of these nutrients due to various genes, and are sensitive to heavy metals and pesticides due to variants in MTHFR 1298 and PON1, it stands to reason that your fertility will be more affected by alcohol and coffee.

Non-organic wine may have concentrated amounts of pesticides, insecticides and fungicides, while non-organic beer may be high in glyphosate (Round Up). In California, conventionally-grown wine grapes received more pesticides than almonds, table grapes, tomatoes or strawberries. Residual concentrations of many different pesticides have been detected in bottled wine were similar to initial concentrations on the grapes. France also appears to be a heavier user of pesticides. Italy and Argentina have been found to have wine most likely free from pesticides and heavy metals.

Women who experienced hangovers were more likely to be infertile than women who did not experience hangovers, suggesting that the amount of alcohol consumed does matter. Amounts of alcohol ranging from one drink a week to 5 a day can have various effects including increasing the time to pregnancy, decreasing the probability of conception by over 50% and decreasing implantation rate.

Coffee depletes b-vitamins and magnesium due to its diuretic effect, and may be heavily sprayed with pesticides and contain mycotoxins due to storage. Non-organic coffee is one the heaviest sprayed crops with pesticides, and chemicals used may not fall under the same regulations of banned chemicals as the United States.

Further Reading

For further reading, check out All Health Starts in the Cell Membrane, Nitric Oxide: A Key Understanding Inflammation and DNA Damage, Replication and Repair and you will have the three pillars to increasing fertility and preventing disease.