Estrogen and progesterone have tremendous influence over numerous physiological actions. One of the most common associations with imbalanced hormones is the effect on mood. This can be debilitating for some women when their hormones are bouncing between extremes. You may experience both high estrogen symptoms and low estrogen symptoms depending on the time of your cycle and epigenetic influences. Understanding how epigenetic factors like diet, medications, and environment influence your hormones can help you become proactive in achieving balance throughout each month of your cycle, and during post-menopause.

The Nutrition Genome Report can help you determine which genes need the most attention, like MAO, COMT, CYP1A1 and CYP1B1, along with genes related to higher needs of certain vitamins and minerals for optimal hormone function. 

What are the Symptoms of High Estrogen?

Chronically high estrogen levels can lead to anger, irritability, anxiety, worry, panic attacks, fatigue, insomnia, weight gain, bad PMS and cramps, allergies, blood clots, fibroids, endometriosis, and hormone-related cancers.

What Causes High Estrogen or Estrogen Dominance?

In the estrogen pathway, the enzymes MAO, COMT, CYP1A1 and CYP1B1 all govern the speed at which serotonin, estrogen, dopamine, and epinephrine are increased and decreased. Low and high levels of any of these neurotransmitters will lead to depression or anxiety.

For pre-menopausal females, the menstrual cycle gives rise and fall in estrogen, progesterone, and serotonin. As estrogen rises, so does serotonin. As it goes down, so does serotonin. Estrogen influences pain transmission, headache, dizziness, nausea, and depression through serotonin signaling. When these swings happen in extremes, the feelings of anxiety and depression can be amplified. While serotonin is mainly thought of as a mood-elevating neurotransmitter of the brain, only 1% of serotonin is found in the central nervous system. The remaining 99% is found in the gut and immune tissues regulating gut motility, vasodilation, clotting, immune cells and uterine contractions.

One of the biggest disruptors of this pathway is chronic stress and trauma. Stress slows this pathway down, leading to high estrogen, serotonin, dopamine and adrenaline levels. The body can get stuck in fight or flight from chronic stress, causing you to feel very reactive and eventually leading to your body burning out.

Xenoestrogens are synthetic estrogens that are ubiquitous in personal care products, plastic water bottles, and the environment. These xenoestrogens act like estrogen in the body, causing excess levels that your liver struggles to detoxify. Choosing natural care products with ingredients you can pronounce, glass bottles and organic foods help reduce your exposure to xenoestrogens dramatically.

If you have a history of antibiotic use or digestive elimination problems, estrogen can become deconjugated, reabsorbed and reactivated in the blood leading to estrogen dominance and wide swings in serotonin. Research has proposed that the microbiome contributes to breast cancer growth by modifying systemic estrogen levels. The Cleveland Clinic recently identified differences in the microbiome of breast cancer patients, showing a profound difference in bacteria.

IBS is a condition of serotonin (and glutamate) rushes and shortages and the consequential estrogen dysregulation. Fibromyalgia is another condition believed to be linked to estrogen and serotonin levels due to altered tryptophan metabolism (precursor to serotonin) and is observed in more females than males.

How Do You Lower Excessive Estrogen?

Increasing your fiber intake (certain fruits, legumes, vegetables, nuts and seeds), magnesium, foods that contain natural aromatase inhibitors (white button mushrooms, oranges, lemons grapefruit), cruciferous vegetables (broccoli, cauliflower, bok choy, cabbage, Brussels sprouts), iodine and omega-3’s all help balance estrogen.

What are the Symptoms of Low Estrogen?

Very low levels of estrogen can cause depression, low libido, poor concentration and memory, migraines, fatigue, bone loss, osteoarthritis, chronic pain, UTI’s, infertility, and cardiovascular disease.

Estrogen has antioxidant properties due to its ability to bind to estrogen receptors and to up-regulate the expression of antioxidant enzymes. Estrogen receptors have been identified in the mitochondria (see the ESR2 gene found in the Nutrition Genome Report). Estrogen is actually protecting the mitochondria, and therefore conditions related to mitochondrial dysfunction need to be viewed through both hormone levels and relevant gene SNPs.

What Causes Low Estrogen?

Menopause, hysterectomy, autoimmune disorders, chemotherapy and radiation treatment, very low body fat percentage, anorexia, excessive exercise as seen in female competitive athletes, and excessive caffeine intake.

How to Raise Low Estrogen

Determining the cause of chronically low estrogen levels is helpful in determining the best strategy.

If it is due to menopause, increasing foods high in phytoestrogens like flax seeds and hops during this time period helps bring relief due to phytoestrogens binding to estrogen receptors and upregulating serotonin receptors. Maintaining a diet high in phytoestrogens may assist throughout the post-menopausal period for estrogen, serotonin levels and preventing bone loss.

If it is due to low body fat percentage, an eating disorder, or excessive physical training, talk to your doctor regarding your concerns and a plan going forward.



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